The science of wound healing
Wound healing is a complex process requiring the collaborative efforts of different tissues and cell lineages involving the coordinated interplay of several biological processes and phases.
Three stages of the healing process have been identified; inflammation, proliferation (which involves cell migration, matrix synthesis and contraction) with the final stage being maturation or remodelling.
Damage to tissue triggers a robust influx of inflammatory cells (leukocytes) to the wound site that also play key roles in clearing the wound of invading microbes but conversely may release signals that can be detrimental to repair. Inflammation is an essential stage of wound healing but a protracted inflammatory phase can lead to a wound not following the other two stages correctly and may lead to a wound becoming slow to heal, non healing or fibrosis.
A Class IIa medical device.
Electroceutical research is developing medicines that use electrical energy to modulate the body's neural circuits and other physiological functions where electrical energy is used to initiate biological change.
Accel‑Heal® addresses one of the key reasons why wounds fail to follow a normal healing trajectory, without having to flood the system with molecular medicines that inevitably have secondary or sometimes deleterious effects.
The electrical sequence pulses delivered from Accel-Heal® helps normalise the over-expression of specific cells in the inflammatory phase, restoring cell to cell junctions leading to improved collective keratinocyte migration and thus wound closure and integrity of the extra cellular matrix. This is far beyond classical approaches of electric field and electrical stimulation type applications where the approach has been non specific and blunt in comparison.
Accel‑Heal® in clinical practice
Over 90 clinical settings across the UK have now evaluated Accel‑Heal® and found that it improves healing rates and quality of life for patients, as well as significantly reducing pain and exudate. In a survey conducted in early 2014, 100% of clinicians surveyed who tried Accel‑Heal® said that they would recommend Accel-Heal.
An innovative programme of research was also conducted with the Wellcome Trust Cell-Matrix Laboratory at The University of Manchester under the direction of Professor Karl Kadler.
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